Biology Core
Epidemiology and Statistics Core
It will monitor the epidemiological literature, with a particular interest in gene-environment interactions, and will regularly provide updates on recent findings. It will also monitor the statistical literature for relevant methods that can be used within the Consortium.
Members of the consortium will also be able to consult the core for questions on study design, analysis, and presentation of results.
Core Leaders: Alexis Elbaz, George Mellick, Karin Wirdefeldt
Clinical Core
The objectives of the Clinical Core are also to provide a standard dataset of basic clinical assessments that can be used by each site, using site-specific access, in a web-based REDCap system. This will facilitate future data sharing in upcoming projects within the Consortium.
The clinical database will not only comprise data on idiopathic Parkinson’s disease but also other forms of neurodegenerative parkinsonism, i.e. PSP, MSA, CBS. The database will also be built to capture and allow analyses of therapeutic outcomes, to integrate information on pharmacological treatment and device-based interventions i.e. deep brain stimulation (DBS) or pumps (LCIG, apomorphine).
It will be the Clinical Core’s responsibility (i) to create a basic dataset, that is harmonized based on current state-of-the-art diagnostic criteria and clinical scores, and (ii) to maintain a comprehensive, regularly updated searchable database of clinical data for the Consortium in collaboration with the Bioinformatics Core.
Core Leaders: Rejko Krüger, Beom Jeon, Katerina Markopoulou
Genomics/Data Science
Part of our objective is to develop a standardized analytical pipeline to seamlessly perform downstream genomic analyses, to use either next-generation sequencing data (exome, genome, resequencing) or candidate SNP data generated via different genotyping platforms. However, the Bioinformatics/Genomics core also serves to integrate data generated by different cores (i.e. Epidemiology core, Clinical core, Biology core) with raw genomic data. As such the Core will be responsible for developing and managing a “GEoPD database”, containing genomic data accessible to GEoPD members.
The Genomics/Data Science broader mission is to help GEoPD investigators perform novel, multi-dimensional, clinico-genetic-epidemiological studies.
Core Leaders: Manu Sharma
Communications Core
Core Leaders: Matthew Farrer, Christine Klein, Rejko Krüger
